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Croda Bioprocess for Cosmetic Ingredient


Develop a route to ODA from renewable raw materials.


Octadecenedioic acid (ODA) is a versatile ingredient used in cosmetic applications. A key property is the lightening of skin and is used in creams to even out the tone in complexions and treat skin pigmentation disorders by stopping the biosynthesis of melanin. However the ingredient is very difficult to access commercially via conventional chemistry.


British speciality chemicals company Croda developed a biotransformation of oleic acid, a fatty acid found in various animal and vegetable sources, to ODA.

Croda invested in building production-scale fermentation facilities at their manufacturing site in Widnes, UK, in 2009. The new plant has high flexibility in handling various pH environments and high salt concentrations.


Renewable feedstock
Mild, low impact process
Natural ingredient

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